Moreover, PnTx2-6 enhances cavernosal leisure in strips isolated from diabetic computer mice and eNOS knockout mice (Nunes et al., 2012b). For detumescence to occur, the process requires to invert towards vasoconstriction, which includes the hydrolysis of cGMP by phosphodiesterase kind 5 (PDE5) and activation of the Rho-kinase pathway. Any inequality in these pathways, may trigger…